Comparison of Sedative and Tranquilizer Drugs with Ketamine Hydrochloride for General Anaesthesia in Rabbits

The aim of the present study was to compare the effect of (detomidine 150 mg/kg) mixed (Ketamine 35mg/kg) in one syringe with (Acepromazine 2mg. /Kg B. W.) mixed (Ketamine 35mg/kg) in one syringe. First protocol uses detomidine and Ketamine in one syringe administered intramuscularly and the second protocol uses acepromazine and ketamine in one syringe administered intramuscularly. Data were collected immediately before administration of drugs (zero time) as control data. Parameters included clinical measures: Heart rate, respiratory rate, rectal temperature, analgesia at time 5, 20, 15, 20, 25, 30, and 50 minutes. The results revealed that detomidine has sedative and analgesic effects. Whereas the acepromazine ketamine protocol shows that the acepromazine has mild to moderate tranquillization and muscle relaxation, but adverse effects do not have a property of analgesia. Last protocol shows a weaker analgesia and unconsciousness as compared with first protocol which was stronger analgesia and deep unconsciousness. Both protocols showed a decrease in the plus rate, respiratory rate and body temperature. The two protocols were analyzed in terms of analgesia and sedation level, and duration of anesthesia. In conclusion, the injection of (detomidine Ketamine) is suitable to from an injection of (acepromazine ketamine), because induction period is shorter and more surgical anesthesia, with long period of recovery time.